Ipamorelin and CJC-1295 are contraindicated in any oncological context — both confirmed diagnosis and clinical suspicion.

Both compounds stimulate pituitary GH release, which in turn drives hepatic IGF-1 synthesis. IGF-1 is a well-characterised mitogen that activates the PI3K/AKT/mTOR and RAS/MAPK proliferative cascades, suppresses apoptosis, and…

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Muito obrigada Audre… Essa era a minha preocupação mas queria saber também outras opiniões!

Thank you very much Andrea. Tomorrow i will meet the patient and request the additional info.

Before considering Ipamorelin or CJC-1295, could you please provide additional information regarding the tumor biology, including ER, PR, HER2 status, Ki-67, disease stage, and current chemotherapy regimen?

In general, I am cautious with GH secretagogues such as Ipamorelin and CJC-1295 in patients with active breast cancer, as they may…

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recomendação geral é de não utilizar em pacientes com câncer ativo e ter muita cautela em pacientes com histórico de câncer, principalmente sem liberação do oncologista. Isso ocorre porque o CJC-1295 aumenta a secreção de hormônio do crescimento (GH) e consequentemente pode elevar os níveis de IGF-1.

Good evening, everyone!

I have a patient with breast cancer who is still undergoing chemotherapy. She is an athlete and has been responding well to both her medications and treatment.

In addition to Thymosin Alpha-1, would it be reasonable to consider Ipamorelin and CJC-1295 to help maintain body composition and lean muscle mass during…

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Great question, and whilst I can only comment as a transformation and optimisation coach rather than a practitioner, having worked across nutrition, hormones, blood chemistry and peptides for over 10 years I’ve seen this play out time and time again.

Most people are chasing the headline treatments and ignoring the very thing that makes them…

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Estoy totalmente de acuerdo, tratar el terreno es fundamental

Writing about the progress of our patient, starting this week MSCs IV. Completely off mesalazine and azathioprine.

Entering cellular therapy with inflammatory markers (CRP, lactoferrin, calprotectin) presenting a significant delta for better. Lower yet there is still a manageable inflamation for homing.

Patient has reported energy like…

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Muchas gracias por la respuesta doctora. Excelente voy a revisar las recomendaciones. Muy agradecido!!

Excelente plan de abordaje doctor.

Todo lo que presenta la paciente indica Endotoxemia, sería interesante ver su Microbiota y tratar LeakyGut.

Me encantaría saber su evolución

Va a depender del paciente que tenga delante. Exosomas son más versátiles, te permiten la modulación previa y actúan ellos mismos también como terapéuticos sobre las stem cell residentes, son pequeños por lo permiten usos más generales, no tienen efecto regenerador o scaffold perse. Células requieren mayor precisión en su uso, tienen efecto…

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Exacto… creer que las terapias regenerativas hacen magia sin tener en cuenta terreno y fisiopatogenia.

Super interesante el caso doc. En esta pcte pensaría en modular muy bien terreno (inmunológica, inflamatorio, metabólico) y sobre todo cual fue el gatillo sistémico reciente (menopausia, Disbiosis, tiroides, Insulina, Cortisol, etc). Haría un abordaje en tres tiempos:

1- Terreno: NAC, NAD+, omega, Vit. A, E, C, Zn, Se. Algún drip también.

2-…

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Paciente femenina de 56 años, conocida hipertensa en tratamiento con Ziac 5 mg por día.

Paciente con vitiligo de aproximadamente 5 años. Desde hace un año empeora el cuadro con afectación de manos, codos, pies, cuello, espalda.

Quisiera aportes sobre tratamientos medicina regenerativa y protocolos con peptidos, exosomas, etc.

Muchas gracias.

Dr.…

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In my opinion, one of the most underrated tools is actually the proper preparation of the biological terrain, including metabolic optimization, gut health, inflammation control, and mitochondrial support. Many practitioners focus on advanced therapies, but without this foundation, results can be limited or inconsistent.

Excelente pregunta. En mi opinión médica, la elección depende del objetivo terapéutico y del nivel de intervención biológica que buscamos en cada paciente.

Sumando los péptidos a mi comentario, los exosomas y las células madre no compiten entre sí, sino que cumplen roles biológicos complementarios: los <strong data-start=”358″…

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Thank you for sharing this case, and welcome to the community!

You’re doing a great job managing a very complex patient. It’s encouraging to see her clinical improvement and how structured and thoughtful your approach has been so far.

The issue with lab orders across systems is something many of us face—hopefully you can find a local…

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Hello everyone,

Roberto Vallarino M.D.

Physician from Panama city, Panama. Great to have a community to bring up questions and discussion. Very thankful for responses.

Ive had 2 years of Regenerative Medicine practice.

Currently with a upcoming case of autoimmune hep (confirmed), concomitant ulcerative colitis & graves disease

My patient is a…

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Si tuviéramos que elegir en nuestra práctica clínica una de las dos, que tipo de terapia celular eligirian stem cells o exosomes ?? A cual terapia celular apunta el futuro de la medicina estética ?

Optimize the hormonal and metabolic field. Assess nutritional deficiencies and you will find your practice to be objective.

When these fields are optimal and supplemental deficiencies are being addressed, the therapeutic outcomes are solid. Most regenerative medicine therapies are sinergical: MSCs, exosomes, peptides, light therapy,…

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Im sure that in order to establish Regenerative Medicine in its imminent position; the regulatory aspect of everything represents a challenge.

What works for me is to be as clear as possible regarding the biological agent I use, the patient must know the evidence as it stands at the day and must know that there are moments/instances were we…

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Hace tiempo atrás el primer desafío era encontrar un buen protocolo, después había que educar al paciente, cuando el paciente estaba convencido… había que decirle el precio! Era una batalla sin fin. Cuando por fin los pacientes venían directamente a preguntar por Regenerativa… un influencer lo convenció de que lo ideal sería colocar 1…

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I’ve seen the lack of standardized protocols.

There are a lot of influencers and coaches just dosing what they heard from a viral video

For doctors who have already integrated regenerative medicine into their practice — what was the biggest challenge in the beginning?

• Patient education

• Pricing

• Training

• Clinical protocols

Curious to hear your experience.

There are a lot of exciting technologies emerging in regenerative medicine.

In your opinion, what’s the most underrated tool or therapy that more practitioners should be paying attention to right now?

Every practitioner develops a protocol that changes the game for their patients.

What’s one regenerative protocol (PRP, exosomes, peptides, biologics, etc.) that significantly improved your outcomes?

What made the difference?